Manuscript Preparation

Manuscript Formatting


  • Text should be 1.5-spaced.
  • Typeface should be Times/Times New Roman or similar serif typeface.
  • Do not use a sans serif typeface (eg, Arial/Helvetica).
  • Body text size should be no smaller than 10 pt and no larger than 12 pt.
  • Page size should be US Letter.
  • To assist reviewers, please include page numbers in the manuscript file.


Manuscripts must be submitted with both a full title and a short title, which will appear at the top of the PDF upon publication if accepted. Only the full title should be included in the manuscript file; the short title will be entered during the online submission process.

The full title should be specific, descriptive, concise, and comprehensible to readers outside the subject field. Avoid abbreviations if possible. Where appropriate, authors should include the species or model system used (for biological papers) or type of study design (for clinical papers).

Authors and Affiliation

All author names should be listed in the following order:

  • First names (or initials, if used),
  • Middle names (or initials, if used), and
  • Last names (surname, family name)
  • Medical and/or highest academic degrees (eg, MD, PhD)

Each author should list an associated department, university, or organizational affiliation and its location, including city, state/province (if applicable), and country.

When a large group or center has conducted the work, the author list should include the individuals whose contributions meet the authorship criteria defined above, as well as the group name. If the article has been submitted on behalf of a consortium, all author names and affiliations should be listed at the end of the article in the Acknowledgements section.

At least one author should be designated as the corresponding author, and his or her email address should be included on the manuscript cover page. This information will be published with the article if accepted. SIM allows the manuscript to have up to four corresponding authors.

For questions regarding authorship requirements, please consult the ICMJE Uniform Requirements for Manuscripts Submitted to Biomedical web page at

Title Page

The Title Page should include all the general information about the manuscript as follows:

  • Title: With no more than 20 words, concisely reflects the core contents of the manuscript.
  • Authors: Different categories of manuscript have different requirement for the number of authors, please refer to the above description. SIM allows a maximum of 4 authors having equal contribution to the work. Authors should be marked with “*, †, ‡, ¶, §, ||, ¦¦, **, ††, ‡‡, ¶¶, §§” in sequence. Corresponding author(s) should be labeled with “∆”.
  • Author Affiliations: List all affiliations of the authors in sequence as they are appeared with the corresponding marks above.
  • Correspondence to: Provide contact information of the corresponding authors including email address, telephone number and fax number. SIM allows 4 corresponding authors from different institutes, but only 2 corresponding authors from the same institute.
  • Running Head: Please provide a short title with no more than 6 words.
  • Funding: If the work was supported by any kinds of financial sources, please provide detailed information on these providers with the reference IDs.
  • Conflict of Interests: A declaration on the conflict of interests is required on the title page. Besides, you need sign the Conflict of Interests form and submitted it accompanying to your submission.
  • Acknowledgements: Type your acknowledgements on the Title Page if you have. Do not follow it at the end of the discussion.
  • Author Contributions: Give a detailed description on each author’s contribution to the work.
  • Abbreviations: Please list all the abbreviations appeared in the paper like “CNS: central nervous system” with only one each line.
  • Keywords: SIM requires 3-8 keywords for each paper.
  • Metadata: You need provide the words count of the abstract or summary, body text; and the number of references, figures, color figures, and tables.


The research article should include structured abstract, but other types of submission do not need to structure their abstract. All submissions need to include an abstract with 250-350 words if the word limitation was not specified above.

Body of the Manuscript

The overall structure of your manuscript text should be in compliance with the corresponding reporting guideline. For example, a CONSORT compliant manuscript should include the following sections, as defined by the CONSORT checklist:

  • Introduction
  • Methods
  • Results
  • Discussion
  • Other Information


All contributors who do not meet the criteria for authorship should be listed in an “Acknowledgements” section. Additionally, if the article has been submitted on behalf of a consortium, all author names and affiliations should be listed at the end of the article in the Acknowledgements section. Authors should also disclose whether they had any writing assistance.


SIM has her special requirements on the references. Taking into consideration of the copyright and efforts the authors made, SIM requires list all the authors of the reference. The references should be appeared in sequence in Arabic number in parentheses like “(1)” in the text. Please format your references as following examples:

Published journal article:

Samaan Z, Mbuagbaw L, Kosa D, Debono VB, Dillenburg R, Zhang S, Fruci V, Dennis B, Bawor M, Thabane L. A systematic scoping review of adherence to reporting guidelines in health care literature. J Multidiscip Healthc 2013; 6:169-88.

Journal online ahead publication:

Stevenson JR, Villoria N, Byerlee D, Kelley T, Maredia M. Green Revolution research saved an estimated 18 to 27 million hectares from being brought into agricultural production. Proc Natl Acad Sci USA 2013; In press.

Web reference:

Shine on: photos of dazzling mineral specimens. Last accessible date: May 15, 2013. Available from:

Book chapter:

Daniel N. Miller and Raymond A. de Callafon. Identification of linear, discrete-time filters via realization. Linear Algebra - Theorems and Applications. Yasser H (Ed.), ISBN: 978-953-51-0669-2, InTech. 2012; pp1-26.

Meeting abstract:

Toro L, Singh H, Stefani E, Bopassa JC. NS1619-induced cardioprotection against ischemia reperfusion injury is lost after kcnma1 gene ablation (Abstract). A154, ASA 2012 Annual Meeting, Washington DC.


Create tables using the table formatting and editing feature of your word processing software. Do not use Excel or comparable spreadsheet programs. Tables should be self-explanatory and should supplement, rather than duplicate, the material in the text.

  • Tables are text-only items. Do not embed images within the table file.
  • Each table file should include the table title, appropriate column heads, and any legends.
  • Save each table in a separate word processing document file and upload individually.
  • Do not embed tables within the manuscript file.
  • Tables are numbered with arabic numerals (1, 2, 3, etc.) when there is more than one. Do not use roman numerals.
  • Cite tables consecutively in the manuscript, and number them in the order in which they are discussed.
  • Abbreviations are not permitted in table titles. Any abbreviation(s) used in the body of the table, including dashes, must be defined in a footnote to the table, listed in reading order.
  • Many tables include information from other articles and series of patients. In these tables, include the name of the first author of the previous series, and include the reference number and year alongside the author's name. Each series mentioned in a table must be listed in the Reference section.


To ensure the highest-quality reproduction of figures, please follow these guidelines carefully. Science Insights Medicine is not responsible for the quality of images; it is the responsibility of the authors to submit publication-quality, high-resolution images. If you have questions, consult a graphics specialist. The term “Figures” refers to both photographic and computer-generated graphs and charts.

Creating and Saving

  • Art should be created/scanned, saved and submitted as TIFF, EPS, or MS Office (DOC, PPT, XLS) files. High resolution PDF files are also acceptable.
  • Figures are numbered with arabic numerals (1, 2, 3, etc.) when there is more than one.
  • Each file should be saved as the appropriate figure number (eg, Figure 1.tif). Do not include the author name in figure file name.
  • Art should be created or scaled to the size intended for publication.
  • Use scale markers in the image for electron micrographs, and indicate the type of stain used.
  • Image orientation should be the same as intended for publication.
  • Artwork generated from office suite programs such as CorelDRAW, MS Word, MS PowerPoint and artwork downloaded from the Internet (low resolution JPEG or GIF files) cannot be used.

Formatting Specifications

  • File formats appropriate for figures: TIFF, EPS, or MS Office (DOC, PPT, XLS) files. High resolution PDF files are also acceptable.
  • All figures must be designated GRAYSCALE (black and white) or RGB (color).
  • Electronic photographs, radiographs, CT scans, and scanned images must have a resolution of at least 300 dpi (dots per inch). Line art (purely black and white figures with no shades of gray) must have a resolution of at least 1200 dpi. Figures that do not meet the resolution requirement will be returned if necessary.
  • Digital art files should be cropped to remove non-printing borders (such as unnecessary white or black space around an image) and should not include embedded “legend” text, figure titles, or figure numbers.
  • Composite figures may be either submitted as one single print-quality image that is neatly labeled with uppercase letters using Arial/Helvetica bold font or submitted as separate panels (without labels), eg, Figure 1A.tif, Figure 1B.tif, to be combined during production if accepted for publication.


  • Attach a separate file for each individual art submission.
  • Do not embed figures in the manuscript file.
  • Label figures using the Description field provided in the Attach Files section of Editorial Manager (eg, Figure 1, Figure 2). This provides a label for each figure in the PDF generated by Editorial Manager.
  • Cite figures consecutively in the manuscript, and number them in the order in which they are discussed.

Figure Legends

  • Legends for all figures should be brief and specific, and should appear on a separate page at the end of the manuscript document, following the list of references. Legends should indicate the figure number and must be numbered correctly.
  • All symbols or abbreviations appearing in an illustration must be defined in the legend; arrows appearing in a figure should be mentioned in the legend.
  • Legends for composite figures should be formatted as a single legend containing necessary information about each part/panel (not separated).
  • Credit for any previously published illustration must be given in the corresponding legend, and must appear in the style stipulated by the original copyright holder.

Supplemental Content

Authors may submit supplemental digital content to enhance their article’s text. Supplemental digital content may include text documents like questionnaires, graphs, tables, figures, and videos. Supplemental digital content will not appear in the article itself but will appear online, accessible by a URL embedded in the article. Supplemental digital content files are not copy edited; they will be presented digitally as submitted.

Supplemental content should include a sequential number if submitting more than one (1, 2, 3, etc.). Cite all supplemental digital content consecutively in the text. Citations should include the type of material submitted, should be clearly labeled as "Supplemental Digital Content" or “Supplemental Video,” and should provide a brief description of the supplemental content.

Citation Examples:

  • (see Video, Supplemental Video, which demonstrates the degrees of flexibility in the elbow)
  • (see Table, Supplemental Content, which illustrates the rise in cost of knee replacement surgery)
  • Provide a separate set of legends for supplemental digital content at the end of the text, following the figure legend. List each legend in the order in which the material is cited in the text.

Legend Examples:

  • Supplemental Video. Video that demonstrates the degrees of flexibility in the elbow, 5 minutes, 10MB.
  • Supplemental Digital Content. Table that illustrates the rise in cost of knee replacement surgery.

Supplemental Content Size and File Type Requirements

  • Supplemental digital content may be presented in any format (PDF is preferred), and should indicate the article title and first author for clarity.
  • Supplemental video files should be submitted following these requirements:
  • .wmv, .mov, .flv, .qt, .mpg, .mpeg, .mp4 formats only
  • Video files should be formatted with a 320 x 240 pixel minimum screen size.
  • Videos should not exceed 10 minutes in runtime.
  • Videos must include embedded audio narration in English.
  • Video files too large to upload in Submission System, please contact us.

Accepted Manuscripts

Page Proofs or Electronic Proofs

Authors will receive notification via email that the PDF (portable document format) proofs of their article are available. Authors are urged to carefully examine the proofs, correct any inadequacies or inaccuracies, and answer all queries. Only the most critical changes to the accuracy of the content will be made. Changes that are stylistic or are a reworking of previously accepted material will be disallowed. Rewriting sections of text, adapting tables and figures, and/or adding/subtracting references are not permitted at this point in the process. Within 48 hours, corrections or approval should be sent to the Production Editor; a message summarizing the corrections may be sent by email or fax.